Matthew Bidwell Goetz, M.D.
Program Director; UCLA Affiliated Program in Infectious Diseases
Professor of Clinical Medicine, David Geffen School of Medicine at UCLA
Chief, Infectious Diseases Section, VA Greater Los Angeles Healthcare System

Division of Infectious Diseases, 111F
11301 Wilshire Blvd.
VA Greater Los Angeles Healthcare System
Los Angeles, CA 90073
Tel: (310) 268-3015
Fax: (310) 268-4928

Research Interests:
Strategic treatment and long-term complications of HIV Infection
Antimicrobial utilization and infection control

Active research studies include;

VISN-QI: Implementation and Evaluation of a VISN-based program to improve HIV Screening and Testing. Multi-site prospective study of interventions to improve HIV screening and testing rates in the VA funded by A VA Health Services Research and Development Service Directed Project. Principal Investigator.

Veterans Aging Cohort Study (VACS). Multi-site prospective cohort study of 3,000 HIV-infected subjects and 3,000 HIV-negative controls. Funded by the National Institute of Alcohol Abuse and Alcoholism. Co-investigator.

ESPRIT: A randomized, open-label, phase II, international study of subcutatenous recombinant IL-2 (Proleukin(r)) in patients with HIV infection and CD4+ >300/mm3: evaluation of subcutaneous Proleukin(r) in a randomized international trial (ESPRIT 001). Multi-site prospective study funded by the National Institutes of Allergy and Infectious Diseases. Local site-investigator.

STALWART: Study of Aldesleukin with and Without Antiretroviral Therapy (ESPRIT 002). Multi-site prospective study funded by the National Institutes of Allergy and Infectious Diseases. Local site-investigator.

EXHALE: HIV and Lung Complications in the HAART era: Focus on Obstructive Lung Disease. Multi-site prospective study of pulmonary complications in HIV-infected patients funded by the National Heart, Lung and Blood Institute. Co-investigator.

MED-CHK: Implementing Computerized Clinical Assessment of HIV Patient Adherence. Multi-site prospective study funded by the National Institute of Mental Health of the effectiveness of using a computerized interface to better detect variations in adherence to HIV medications and medication errors and to prompt effective interventions. Co-investigator.

Selected Publications:

  1. Lambertus MW, Goetz MB, Murthy AR, Mathisen GE.  Complications of corticosteroid therapy in patients with the acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia.  Chest.  1990; 98:38-43.
  2. Schwartzman WA, Lambertus MW, Kennedy CA, Goetz MB.  Staphylococcal pyomyositis in patients infected by the Human Immunodeficiency Virus.  Am J Med.  1991; 90:595-600.
  3. Senay H, Goetz MB.  Epidemiology of invasive urinary tract infections in chronically hospitalized, elderly men.  J Urol.  1991; 145:1201-1204.
  4. Goetz MB, Mulligan ME, Kwok R, O'Brien H, Caballes C, Garcia JP.  Management and epidemiologic analyses of an outbreak due to methicillin - resistant S. aureus.  Am J Med.  1992; 92:607-614.
  5. Kennedy CA, Goetz MB.  Atypical roentgenographic manifestations of Pneumocystis carinii pneumonia.  Arch Intern Med.  1992; 152:1390-1398.
  6. Shriner KA, Mathisen GE, Goetz MB.  Comparison of mycobacterial lymphadenitis among persons infected with Human Immunodeficiency Virus and seronegative controls.  Clin Infect Dis.  1992; 15:601-605.
  7. Goetz MB, Sayers JFB.  Nephrotoxicity of vancomycin and aminoglycoside therapy separately and in combination.  J Antimicrob Chemother.  1993; 32:325-334.
  8. Wong RD, Goetz MB, Mathisen GE, Henry D.  Clinical and laboratory features of measles in hospitalized adults.  Am J Med.  1993; 95:377-383.
  9. Goetz MB, O'Brien H, Musser JM, Ward JI.  Nosocomial Transmission of Disease Caused by Non-typeable Strains of Haemophilus influenzae.  Am J Med.  1994; 96:342-347.
  10. Goetz MB, Proctor RA.  Normalization of intracellular calcium:  a sweet solution to neutrophil dysfunction in diabetes?  [Editorial].  Ann Intern Med.  1995; 123:952-954.
  11. Goetz MB.  Relationship between fluconazole dosage regimens and the emergence of fluconazole-resistant Candida albicans.  [Editorial].  AIDS.  1996; 10:335-336.
  12. Ali MZ, Goetz MB.  Meta-Analysis of the Relative Efficacy and Toxicity of Once-Daily versus Multiple Daily Dosing of Aminoglycosides.   Clin Infect Dis.  1997; 24:796-809.
  13. Doranz BJ, Grovit-Ferbas K, Sharron MP, Mao S-H, Goetz MB, Daar ES, Doms RW, O_Brien WA.  A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor. J. Exp. Med. 1997 186: 1395-1400.
  14. Grovit-Ferbas K, Ferbas J, Gudeman V, Sadeghi S, Goetz MB, Giorgi JV, Chen ISY, O_Brien WA.  Potential contributions of viral and host genetic factors in an HIV-1 long term survivor. J Virol.  1998; 72:8650-8658.
  15. Nimmagadda A, O_Brien WA, Goetz MB.  The Significance of Vitamin A and Carotenoid Status in Persons Infected by the Human Immunodeficiency Virus. Clin Infect Dis.1998; 26:711-718.
  16. Nimmagadda AP, Burri BJ, Neidlinger T, O_Brien WA, Goetz MB.  Effect of _-carotene supplementation on plasma Human Immunodeficiency Virus (HIV) RNA levels and CD4+ cell counts in HIV-infected patients. Clin Infect Dis.  1998; 27:1311-1313.
  17. Goetz MB.  Editorial Response:  Are Corticosteroids Useful Adjunctive Agents in the Treatment of Disseminated Mycobacterium avium complex Infection Associated with Human Immunodeficiency Virus Infection? Clin Infect Dis. 1998; 26:687-688.
  18. Miller LG, Goetz MB. Editorial Response:  What is the relevance of anti-retroviral therapy that does not include protease inhibitors?  Clin Infect Dis.  1998; 27:1386-1387.
  19. Rhew DC, Glassman PA, Goetz MB.  Improving pneumococcal vaccine rates:  nurse protocols versus clinical reminders.  J Gen Intern Med.  1999.  14:351-356.
  20. Goetz MB.  Editorial Response: Discordance between Virological, Immunological, and Clinical Outcomes of Therapy with Protease Inhibitors in HIV-Infected Patients.  Clin Infect Dis.  1999; 29:1431-1434.
  21. Bennett CL, Schwartz D, Parade J, Sipler AM, Chmiel JS, DeHovitz JA, Goetz MB, Weinstein RA.  Delays in tuberculosis isolation and suspicion among persons hospitalized with HIV-related pneumonia.  Chest 2000; 117:110-116.
  22. Arozullah AM, Yarnold PR, Weinstein RA, Nwadiaro N, McIlraith TB, Chmiel JS, Sipler AM, Chan C, Goetz MB, Schwartz DN, Bennett CL.  A new preadmission staging system for predicting inpatient mortality from HIV-associated Pneumocystis carinii pneumonia in the early highly active anti-retroviral therapy (HAART) era.  Am J Respir Crit Care Med.  2000; 161:1081-1086.
  23. Goetz MB, Morreale AP, Rhew DC, Berman S, Ing M, Eldridge, D, Justis J, Lott E. Effect of Highly Active Anti-Retroviral Therapy on Outcomes in Veterans Affairs Medical Centers.  AIDS.  2001; 15:530-532.
  24. Goetz MB, Wiley D, Boscardin J, Alkasspooles S.  Relationship Between Patient Age and CD4+ Lymphocyte Repletion Following Successful Virologic Responses to Highly Active Anti-Retroviral Therapy.  AIDS.  2001;15:1576-9.
  25. Kim B, Lyons TN, Parada JP, Uphold CR, Yarnold PR, Hounshell JB, Sipler AM, Goetz MB, DeHovitz JA, Weinstein RA, Campo RE, Bennett CL.  HIV-related Pneumocystis carinii Pneumonia in Older Patients Hospitalized in 1995-1997.  J. Gen. Intern. Med. 2001; 16:583-589.
  26. Rhew DC, Goetz MB, Shekelle PG.  Evaluating Quality of Care for Patients with Community-Acquired Pneumonia.  The Joint Commission Journal on Quality Improvement.  2001; 27:575-590.
  27. Feikin DR, Elie CM, Goetz MB, Lennox JL, Carlone GM, Romero-Steiner S, Holder PF, O_Brien WA, Whitney CG, Butler JC, Breiman RF.  Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults.  Vaccine.  2001; 20:545-553.
  28. Rabeneck L, Menke T, Simberkoff MS, Hartigan PM, Dickinson GM, Jensen PC, George WL, Goetz MB, Wray NP. Using the national registry of HIV-infected veterans in research. Lessons for the development of disease registries, J Clin Epidemiol.  2001;54:1195-1203.
  29. Goetz MB, Feikin DR, Lennox JL, O_Brien WA, Elie CM, Butler JC, Breiman RF.  Viral Load Response to a 7-valent Pneumococcal Conjugate Vaccine, Polysaccharide Vaccine or Placebo among HIV-infected Patients.  AIDS.  2002; 16:1421-1423.
  30. Hinkin CH, Castellon SA, Durvasula RS, Hardy DJ, Lam  MN, Mason KI, Thrasher D, Goetz MB, Stefaniak M.  Medication adherence among HIV+ adults:  effects of cognitive dysfunction & regimen complexity. Neurology. 2002;59:1944-50.
  31. Feldman RB, Rhew DC, Charles, RA, Goetz MB.  Azithromycin Monotherapy for Patients Hospitalized with Community-Acquired Pneumonia:  4_-year Experience from a VA Hospital. Arch Intern Med.  2003; 163:1718-1726.
  32. Rhew DC, Bernal M, Aguilar D, Iloeje U, Goetz MB.  Association between Protease Inhibitors and Increased Cardiovascular Risk in HIV-infected Patients: A Systematic Review.  Clin Infect Dis.  2003; 37:959–72.
  33. Parada JP, Deloria-Knoll, Chmiel JS, Arozullah AM, Phan L, Ali SN, Goetz MB, Weinstein RA, Campo R, Jacobson J, Dehovitz , Berland D, Bennett CL.  Relationship between Health Insurance and Medical Care for Patients Hospitalized with Human Immunodeficiency Virus–Related Pneumocystis carinii Pneumonia, 1995–1997: Medicaid, Bronchoscopy, and Survival.  Clin Infect Dis.  2003; 37:1549-1555.  
  34. Sureka S, Deloria-Knoll M, Chmiel JS, Phan L, Lyons TM, Ali S, Parada JP, Yarnold PR, Weinstein RA, DeHovitz JA, Jacobson JM, Goetz MB, Campo RE, Berland D,. Bennett CL, Uphold CR.   HIV-Related Pneumonia Care in Older Patients Hospitalized in the Early HAART Era.  AIDS Patient Care STDS. 2004; 18:99-107.
  35. Korthuis PT, Asch SM, Anaya HD, Morgenstern H, Goetz MB, Yano EM,  Rubenstein LV,  Lee ML, Bozzette SA.  Lipid Screening in HIV-infected Veterans.  JAIDS.  2004.  35:253-260.
  36. Soo Hoo GW, Wen YE, Nguyen TV, Goetz MB.  Impact of Clinical Guidelines in the Management of Severe Hospital-Acquired Pneumonia.  Chest. 2005; 128:2778-2787.
  37. Wiley DJ, Huh J, Rao JY, Chang C, Goetz M, Poulter M, Mansongson E, Chang CI, Bernard HU.  Methylation of human papillomavirus genomes in cells of anal epithelia of HIV-infected men.  J AIDS.  2005; 39:143-51.
  38. Goetz MB, Holodniy M, Poulton JS, Rodriguez FH, Rigsby MO.  Utilization and Access to Antiretroviral Genotypic Resistance Testing and Results within the US Department of Veterans Affairs.  J AIDS.  2006; 41:59-62.
  39. Justice AC, Dombrowski E, Conigliaro J, Fultz SL, Gibson D, Madenwald T, Goulet J, Simberkoff M, Butt A, Rimland D, Rodriguez-Barradas MC, Gibert CL, Oursler KK, Brown S, Leaf DA, Goetz MB, Bryant K. Veterans Aging Cohort Study (VACS): Overview and Description.  Medical Care.  2006; 44:S13-S24.
  40. Goetz MB, Ferguson MR, Han X, McMillan G, St. Clair M, Pappa KA, McClernon DR, OBrien WA. Evolution of HIV Resistance Mutations in Patients Maintained on a Stable Treatment Regimen after Virological Failure.  J AIDS.  2006; 43:541-549.
  41. Braithwaite RS, Kozal M,  Chang CCH, Roberts MS, Fultz S, Goetz MB, Gibert C, Schechter S, Rodriguez-Barradas M, Mole L, Justice AC. Adherence, Virologic and Immunologic Outcomes for HIV-infected Veterans Starting Combination Antiretroviral Therapies.  AIDS 2007; 21:1579–1589.
  42. Kanwal F, Hoang T, Spiegel BMR, Eisen S, Dominitz J, Gifford A, Goetz M, Asch SM.  Predictors of treatment in patients with chronic Hepatitis C virus infection—role of patient versus non-patient factors. Hepatology.  2007; 28:1741-1749.
  43. Braithwaite RS, Roberts MS, Chang CCH, Goetz MB, Gibert C, Rodriguez-Barradas M, Schechter S, Schaefer A. Comparing life expectancy and quality-adjusted life-years with alternative thresholds for initiating HIV treatment.  Ann Intern Med. 2008;148:178-85.
  44. Goetz MB, Bowman C, Hoang T, Anaya H, Osborn T, Gifford A, Asch S.  Implementing and evaluating a regional strategy to improve testing rates in VA patients at risk for HIV, utilizing the QUERI process as a guiding framework: QUERI Series.  Implementation Science.  2008, 3:16 doi:10.1186/1748-5908-3-16.
  45. Parada JP, Yarnold PR, Chmiel JS, Goetz MB, Pallela F, DeHovitz JA, Weinstein RA, Bennett CL. Review of racial variations in care and outcomes for inpatient HIV-related Pneumocystis pneumonia. Journal of Health Care for the Poor and Underserved. 2008. In press.
  46. Sobo EJ, Bowman C, Halloran J, Asch S, Goetz MB, Gifford A. A Routine Thing: Clinician Strategies for Implementing HIV Testing for At-Risk Patients in a Busy Healthcare Organization (and Implications for Implementation of other New Practice Recommendations). Anthropology & Medicine. In press.
  47. Rodriguez-Barradas M, Goulet J, Brown S, Goetz MB, Rimland D, Simberkoff MS, Crothers K, Justice AC. Impact of pneumococcal vaccination by HIV status on the incidence of pneumonia among subjects enrolled in the Veterans Aging Cohort Five-Site Study. Clin Infect Dis. In press.
  48. Anaya HD, Hoang T, Golden JF, Goetz MB, Gifford A, Bowman C, Osborn T, Asch SM. Improving HIV Testing and Receipt of Results by Nurse Rapid Testing and Streamlined Counseling:  A Randomized Controlled Trial. JGIM.  In press.